Malarone or Cloroquine/Proguanil

fdrca · Jun 24th, 2004, 19:36

Dear all,
I am again on the matter MALARIA. I went to the local doctor and he prescribed me Cloroquine + Proguanil. The first one pill one week before leaving and then one a week the second two pills a day, all the therapy to be continued one month after getting back!!! Gosh..and I am staying in India just for 10 days!!! I have heard good things on Malarone. Can anyone who took it drop me a line? I am a bit worried of side effects...but at least the therapy seems not so long!!!Any advice??
Thanks

Federica

Carpe diem quod futura minima postulo!

mr pastry · Aug 23rd, 2004, 20:34

Go with the advise of the Doctor. We have been advised Cloroquine + Proguanil again this time, our last trip was in 1997, so I guess the medical profession still think these are the most suitable for India.

timmy · Aug 23rd, 2004, 20:58

I can't remember which, but one of those two tastes absolutely disgusting. You just can't swallow it fast enough. I think it was the weekly one, I ended up wrapping the pill in a piece of cigarette paper just to get it down without gaggng. If you have some vitamins in capsules maybe open the capsules and empty them and put the pills in to swallow, if necessary.

freenote · Aug 23rd, 2004, 21:03

cloroquine+proquanil seem's the one. Have taken them myself with no side affects at all !!! on the last trip met a german who had been takeing malarone,he had bad side affects ,stopped taking them and went down with malaria!!!!.A small benefit where the days printed on the side of the blister pack, helped keep track of the days

Good travelling and have fun.

mercedes10 · Aug 23rd, 2004, 21:28

I've used chloroquine/proguanil a few times now with no side-effects whatsoever. I know it's not pleasant to think you have to take them for so long, but I think following your Doctor's advice is best - and as I say I've never had a problem with them and nor has anyone else I know. As far as I am aware malarone is not suitable for use in India as I too had asked about it.

goangoangone · Aug 23rd, 2004, 22:23

Here'es some info and links
http://www.malariahotspots.co.uk/index.html
Not all the tablets go well with other medications, ie. blood pressure.

found it http://www.fitfortravel.scot.nhs.uk/

Octathorpe · Nov 19th, 2004, 05:51

Just to be clear, Malarone is the brand name drug that contains two active ingredients, atovaquone (250 mg)and proguanil (100 mg).

Proguanil is also available in several other forms such as Paludrine in the UK. Your basic choice between the proguanil/atovaquone combo in Malarone and the proguanil/chloroquine combo (you buy each separately).

The FDA has apparantly decided that the Malarone combination is more effective and that is what is 'approved' in the States. Everyone else seems to think that the proguanil/chloroquine combo is just dandy. Since the Malarone is so expensive, I choose the latter. I had to buy it in India since I can't buy it in the States. It was hard to find- I have another post with detail on finding it in Delhi:

Malaria

edwardseco · Nov 19th, 2004, 07:05

Have used the Chloroquine and was quite able to swallow it. Still, it is considered much less effective now..

Padma · Nov 19th, 2004, 07:28

There is no telling how you'll respond. i got sick as a dog on chloroquin and proguanil and after 2 weeks of vomiting I gave it away altogether and went with a net at night and DEET. Everyone responds differently, just give it a go and see I guess.

edwardseco · Nov 19th, 2004, 08:45

From what people tell me here that is very much the case with no one size fits all measure..

eater · Nov 19th, 2004, 09:15

Quote:

Originally Posted by edwardseco

Have used the Chloroquine and was quite able to swallow it. Still, it is considered much less effective now..

Could it be that the prescription depends on where one initiates the journey .......protection of national interests?

In Canada the recommended anti-malaria drug seems to be LARIUM (Mefloquine 250mg tablet one per week, continue for four weeks after return from malaria area).

Other recommended drugs are:
1)Malarone (atovaquone/proguanil)
2)Primaquine for special cicumstances;
3)Doxycycline;
4)Chloroquine/proguanil

All probably equally acccchhhh.....

Mamamia · Nov 19th, 2004, 12:19

I also live in canada and my doctor (who is specialized in travel medecine, like yours i hope...

) also recommended Larium. Said that in 99% cases where it caused Psychosis previous mental problems occured. So seems to me that if you have a good medical/mental history ( no axiety crisis and stuff), there will be no problems at all. I myself consider myself sane, so i think i'll go with Larium. And it's much less expensive. (5 bucks a pill but once a week).

Just my two cents.

Jun 24th, 2004, 19:36	#1
fdrca Member Join Date: Feb 2003 Location: Italy Posts: 10	Malarone or Cloroquine/Proguanil Dear all, I am again on the matter MALARIA. I went to the local doctor and he prescribed me Cloroquine + Proguanil. The first one pill one week before leaving and then one a week the second two pills a day, all the therapy to be continued one month after getting back!!! Gosh..and I am staying in India just for 10 days!!! I have heard good things on Malarone. Can anyone who took it drop me a line? I am a bit worried of side effects...but at least the therapy seems not so long!!!Any advice?? Thanks Federica Carpe diem quod futura minima postulo!

Aug 23rd, 2004, 21:03	#4
freenote senior member refused Join Date: Feb 2004 Location: cornwall UK Posts: 1,548	cloroquine+proquanil seem's the one. Have taken them myself with no side affects at all !!! on the last trip met a german who had been takeing malarone,he had bad side affects ,stopped taking them and went down with malaria!!!!.A small benefit where the days printed on the side of the blister pack, helped keep track of the days Good travelling and have fun. __________________ eyes ,eyes that have seen all , come back to the white chrysanthemum (Basho) Last edited by freenote : Aug 24th, 2004 at 00:56.

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Aug 23rd, 2004, 20:34	#2
mr pastry Senior Member Join Date: Apr 2004 Location: United Kingdom Posts: 131	Go with the advise of the Doctor. We have been advised Cloroquine + Proguanil again this time, our last trip was in 1997, so I guess the medical profession still think these are the most suitable for India.

Aug 23rd, 2004, 20:58	#3
timmy Back in Australia Join Date: Nov 2003 Location: Australia Posts: 375	I can't remember which, but one of those two tastes absolutely disgusting. You just can't swallow it fast enough. I think it was the weekly one, I ended up wrapping the pill in a piece of cigarette paper just to get it down without gaggng. If you have some vitamins in capsules maybe open the capsules and empty them and put the pills in to swallow, if necessary.

Aug 23rd, 2004, 21:28	#5
mercedes10 Maha Guru Member Join Date: Sep 2003 Location: Scotland Posts: 556	I've used chloroquine/proguanil a few times now with no side-effects whatsoever. I know it's not pleasant to think you have to take them for so long, but I think following your Doctor's advice is best - and as I say I've never had a problem with them and nor has anyone else I know. As far as I am aware malarone is not suitable for use in India as I too had asked about it.

Aug 23rd, 2004, 22:23	#6
goangoangone Monsoon Loon Join Date: Aug 2004 Location: Goa Posts: 1,535	Here'es some info and links http://www.malariahotspots.co.uk/index.html Not all the tablets go well with other medications, ie. blood pressure. found it http://www.fitfortravel.scot.nhs.uk/

Nov 19th, 2004, 05:51	#7
Octathorpe Member Join Date: Oct 2004 Location: Atlanta, GA USA Posts: 5	Just to be clear, Malarone is the brand name drug that contains two active ingredients, atovaquone (250 mg)and proguanil (100 mg). Proguanil is also available in several other forms such as Paludrine in the UK. Your basic choice between the proguanil/atovaquone combo in Malarone and the proguanil/chloroquine combo (you buy each separately). The FDA has apparantly decided that the Malarone combination is more effective and that is what is 'approved' in the States. Everyone else seems to think that the proguanil/chloroquine combo is just dandy. Since the Malarone is so expensive, I choose the latter. I had to buy it in India since I can't buy it in the States. It was hard to find- I have another post with detail on finding it in Delhi: Malaria

Nov 19th, 2004, 07:05	#8
edwardseco Maha Guru Member Join Date: Sep 2001 Location: Land that shakes and bakes. Posts: 4,141	Have used the Chloroquine and was quite able to swallow it. Still, it is considered much less effective now..

Nov 19th, 2004, 07:28	#9
Padma Member Join Date: Oct 2004 Location: Australia Posts: 77	There is no telling how you'll respond. i got sick as a dog on chloroquin and proguanil and after 2 weeks of vomiting I gave it away altogether and went with a net at night and DEET. Everyone responds differently, just give it a go and see I guess.

Nov 19th, 2004, 08:45	#10
edwardseco Maha Guru Member Join Date: Sep 2001 Location: Land that shakes and bakes. Posts: 4,141	From what people tell me here that is very much the case with no one size fits all measure..

Nov 19th, 2004, 12:19	#12
Mamamia I am canadian. Heh? Join Date: Nov 2004 Location: Montreal Posts: 61	I also live in canada and my doctor (who is specialized in travel medecine, like yours i hope... ) also recommended Larium. Said that in 99% cases where it caused Psychosis previous mental problems occured. So seems to me that if you have a good medical/mental history ( no axiety crisis and stuff), there will be no problems at all. I myself consider myself sane, so i think i'll go with Larium. And it's much less expensive. (5 bucks a pill but once a week). Just my two cents.

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