Anti-malarials may reduce effectiveness of antibiotics

Mickey S · Jul 16th, 2008, 16:52

It's been reported that the use of anti-malarial drugs may reduce the effectiveness of - and may even give rise to resistance to - certain antibiotics.

In particular, it has been found that prolonged use of chloroquinine may be a cause of resistance to Ciprofloxacin.

Full story.

wonderwomanusa · Jul 17th, 2008, 07:53

I don't believe chlorquine has been useful as anti-malarial in India for many years. I've been using doxycycline for at least 15 years, for that reason.

devorenm · Jul 17th, 2008, 09:48

This has been a concern for a while here in the States, it's something my doc and I discussed before my trip (although Chloroquinine wasn't one of the options available for India). For those of us that also take along cipro for GI infections it is something to think about.

Nick-H · Jul 17th, 2008, 11:31

Quote:

Originally Posted by wonderwomanusa

I don't believe chlorquine has been useful as anti-malarial in India for many years. I've been using doxycycline for at least 15 years, for that reason.

It has!

I was prescribed it a couple of years back by a local doc who said it was quite sufficient for the area I was living in.

Chloroquine/proguinal is still discussed in the British NHS guidelines.

HelenR · Jul 17th, 2008, 11:52

CDC guidelines say that Chloroquine isn't effective in India.

I'm usually very skeptical of the CDC says but my travel medicine doctor agreed.

Nick-H · Jul 17th, 2008, 12:08

India's a huge place! Something that may not be good for a traveller covering many different parts of the country can be just fine for a resident living in one part of a city. Chloroquine alone would not be a good recommendation for a traveller, no.

UK authorities are now saying that it is not necessary to take anything in many parts of India. Different national authorities do not give the same advice! Did you see the thread the other day where someone posted that he got conflicting advice from two doctors in the same hospital!

edwardseco · Jul 17th, 2008, 12:42

Drug interactions can also occur. I suppose you DO have to read the fine print. I think I recall that with Doxy. But, when I see another malaria discussion I feel like going to bed early so..

HelenR · Jul 17th, 2008, 12:43

Quote:

Originally Posted by Nick-H

Did you see the thread the other day where someone posted that he got conflicting advice from two doctors in the same hospital!

Wow, I missed that one! Why doesn't that surprise me though...?

I don't expect different countries' authorities to agree when doctors within the same city (let alone the country) can't have a consensus!

While it's good to disagree and foster research, I wish doctors could agree on some basics...

obione980 · Aug 21st, 2008, 18:45

Doxycycline - a malarial prophylactic which is very definitely effective throughout India - is of course, itself an antibiotic!

edwardseco · Aug 21st, 2008, 19:56

Doxy will interfere with certain other drugs such as BC pills. I know, I forgot my resolution..

Jul 16th, 2008, 16:52	#1
Mickey S Maha Guru Member Join Date: Feb 2007 Location: Cymru Posts: 1,176	Anti-malarials may reduce effectiveness of antibiotics It's been reported that the use of anti-malarial drugs may reduce the effectiveness of - and may even give rise to resistance to - certain antibiotics. In particular, it has been found that prolonged use of chloroquinine may be a cause of resistance to Ciprofloxacin. Full story.

Jul 17th, 2008, 07:53	#2
wonderwomanusa Maha Guru Member Join Date: May 2003 Location: Northern California Posts: 3,465	I don't believe chlorquine has been useful as anti-malarial in India for many years. I've been using doxycycline for at least 15 years, for that reason. __________________ The map is not the territory. --Alfred Korzybski

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Jul 17th, 2008, 09:48	#3
devorenm Member Join Date: Jul 2008 Location: Cleveland, OH USA Posts: 10	This has been a concern for a while here in the States, it's something my doc and I discussed before my trip (although Chloroquinine wasn't one of the options available for India). For those of us that also take along cipro for GI infections it is something to think about.

Jul 17th, 2008, 11:52	#5
HelenR Senior Member Join Date: Apr 2008 Location: USA Posts: 108	CDC guidelines say that Chloroquine isn't effective in India. I'm usually very skeptical of the CDC says but my travel medicine doctor agreed.

Jul 17th, 2008, 12:08	#6
Nick-H Loud-mouthed, Noisy Bird Join Date: Oct 2004 Location: Chennai, India Posts: 26,747	India's a huge place! Something that may not be good for a traveller covering many different parts of the country can be just fine for a resident living in one part of a city. Chloroquine alone would not be a good recommendation for a traveller, no. UK authorities are now saying that it is not necessary to take anything in many parts of India. Different national authorities do not give the same advice! Did you see the thread the other day where someone posted that he got conflicting advice from two doctors in the same hospital!

Jul 17th, 2008, 12:42	#7
edwardseco Maha Guru Member Join Date: Sep 2001 Location: Land that shakes and bakes. Posts: 3,910	Drug interactions can also occur. I suppose you DO have to read the fine print. I think I recall that with Doxy. But, when I see another malaria discussion I feel like going to bed early so..

Aug 21st, 2008, 18:45	#9
obione980 Senior Member Join Date: Oct 2005 Location: Brisbane Posts: 135	Doxycycline - a malarial prophylactic which is very definitely effective throughout India - is of course, itself an antibiotic!

Aug 21st, 2008, 19:56	#10
edwardseco Maha Guru Member Join Date: Sep 2001 Location: Land that shakes and bakes. Posts: 3,910	Doxy will interfere with certain other drugs such as BC pills. I know, I forgot my resolution..

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